P 94: The Systemic Inflammation after Spinal Cord Injury

نویسندگان

  • Ali Jahanbazi Jahan Abad Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
  • Maryam Jafari Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Robabeh Jafari Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
  • Sara Abdolahi a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran b. Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
  • Zahra Aeini Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
  • Zeinab Najmi a. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran. b. Microbial biotechnology group, Faculty of Basic Sciences, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده مقاله:

Spinal cord injury (SCI) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms. Neuroinflammation is an important secondary injury process in SCI. The local inflammatory microenvironment within the injured spinal cord is a collection of degenerating neurons, damaged endothelial cells, degraded myelin sheath, and this microenvironment produces various kinds of pro-inflammatory mediators. There are many other factors such as dysregulation of the neuroendocrine system and changed neuroimmune regulation that important determinant of the onset and progression of post-SCI systemic inflammation. Epidemiological analyses have unfolded a functional link between systemic inflammation and pathogeneses of post-injury complications. On the other hand cognitive impairment is associated with extensive cerebral inflammation after SCI. SCI triggers systemic inflammatory responses marked by increased circulation of immune cells and pro-inflammatory mediators, which result in the permeation of inflammatory cells into secondary organs and durability of an inflammatory microenvironment that chip in organ dysfunction. 

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p 94: the systemic inflammation after spinal cord injury

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عنوان ژورنال

دوره 5  شماره 2

صفحات  125- 125

تاریخ انتشار 2017-04

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